Body: 316L stainless steel Window: Proprietary material, optimized for bioprocesses Surface finish: Ra 15 with Electropolish to ASME BPE SF4 finish Adhesive: USP Class VI and ISO 10993 compatible
The Raman flow cell meets the speed demands of downstream by optimizing Raman collection for low-turbidity, low volume samples. Ideally suited for development-scale flow rates, the Raman flow cell allows real-time monitoring, rapid process optimization, and process control for chromatography and other downstream unit operations.
Downstream: aggregation, protein crystallization, formula stability, product CQA, protein concentration, buffer excipients
Provides continuous, real-time measurements with high sensitivity for development-scale flow rates
Achieves lower limits of detection through enhancement of the Raman signal
Brings Raman-based process insights and control to downstream bioprocessing unit operations
Ramanova spektroskopie – pokročilá technologie pro optickou analýzu
Zvyšte bezpečnost provozu, zajistěte kvalitu výrobků a optimalizujte řízení. Ramanova spektroskopie měří složení a molekulární strukturu vašich vzorků v reálném čase – z laboratoře přímo do procesu.
KBI Biopharma is monitoring a diverse array of cell lines and cell concentrations in minimal volume for automated cell cultivation in the Life Sciences industry.
Raman downstream process measurement of biosimilars - Alvotech’s testing of the protein purification process during ultrafiltration/diafiltration (UF/DF)
Operating: 0 to 40 °C / 32 to 104 °F Storage: -20 to 60 °C / -4 to 140 °F
Relative humidity
Storage: < 90 % Non-Condensing
Unit dimensions (width x height x depth)
46 x 25 x 11 mm 1.8 x 1.0 x 0.4 inch
Sampling probe compatibility
Raman Rxn-10
Sampling optic compatibility
micro flow bench
Pressure
Max pressure: 4.8 barg / 70 psig
Wetted materials
Body: 316L stainless steel Window: Proprietary material, optimized for bioprocesses Surface finish: Ra 15 with Electropolish to ASME BPE SF4 finish Adhesive: USP Class VI and ISO 10993 compatible
Sterilization method
CIP/SIP
Process connection
5/16-24 flat bottom ferrules Up to 3/16 inch OD tubing
Endress+Hauser - your one-source Life Sciences technology partner
PU (publikace)
Anglická verze - 06/2024
New version available in English
Graphic highlighting why Endress+Hauser is trusted by the world's top biopharmaceutical manufacturers for its Life Sciences expertise and reliable inline, real-time measurement technologies like Raman spectroscopy systems (Raman Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve, flow cell and flow bench, Raman optic system for single use) and liquid analysis sensor technology (Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E, CLS82E).
Prioritize scalability for an efficient biopharmaceutical
product development lifecycle
PU (publikace)
Česká verze - 09/2024
New version available in English
This technical paper studies the importance of scalability as a competitive advantage in bioprocessing in the Life Science industry, and Endress+Hauser's scalable Raman systems (Raman Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve, flow cell and flow bench, Raman optic system for single use) and liquid analysis sensor technology and Liquid Analysis portfolio (Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E, CLS82E).
Raman flow assembly - Precise composition measurement of
high-speed, low-volume samples in downstream bioprocessing
PU (publikace)
Anglická verze - 05/2023
New version available in English
An overview of the Raman flow assembly (flow bench and flow cell) used with the Rxn-10 probe in conjunction with a Raman Rxn2 analyzer and a Raman flow assembly calibration and verification kit for downstream bioprocessing (powered by Kaiser Raman technology).
Raman calibration and verification kits - Everything needed to
calibrate and verify your Raman analyzer system for lab-to-process
scalability
PU (publikace)
Anglická verze - 12/2023
New version available in English
An overview of the Raman calibration and verification kits for the bio multi optic / single use optic and the Raman flow assembly (includes the flow bench and flow cell). These kits are to be used in conjunction with the Rxn-10 probe and Raman Rxn2 / Rxn4 analyzer for upstream and downstream bioprocessing (powered by Kaiser Raman technology).
Prioritize scalability for an efficient biopharmaceutical
product development lifecycle
PU (publikace)
Anglická verze - 06/2024
New version available in English
This technical paper studies the importance of scalability as a competitive advantage in bioprocessing in the Life Science industry, and Endress+Hauser's scalable Raman systems (Raman Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve, flow cell and flow bench, Raman optic system for single use) and liquid analysis sensor technology and Liquid Analysis portfolio (Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E, CLS82E).
Lab-to-process monitoring & control in Life Sciences -
Reliable measurement of bioprocess physical and
chemical properties
PU (publikace)
Anglická verze - 04/2024
New version available in English
A combined product list of analysis offerings from both Optical Analysis and LIquid Analysis for bioprocessing applications in the life science industry (including Raman Rxn2 analyzer, Raman Rxn4 analyzer, Rxn-10 probe, bio multi optic and bio sleeve, Raman flow assembly, Rxn-45 probe, Rxn-46 probe, Raman optic system for single use, Memosens CPS61E, Memosens COS81E, OUSBT66, Memosens CPS61E, Memosens CPS77E, Memosens CLS82E, OUSAF44, Memosens CPS11E, Memosens CLS16E, TOC Analyzer CA79, Liquiline transmitter platform, and Memobase software).
Endress+Hauser - your one-source Life Sciences technology partner
PU (publikace)
Česká verze - 09/2024
New version available in English
Graphic highlighting why Endress+Hauser is trusted by the world's top biopharmaceutical manufacturers for its Life Sciences expertise and reliable inline, real-time measurement technologies like Raman spectroscopy systems (Raman Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve, flow cell and flow bench, Raman optic system for single use) and liquid analysis sensor technology (Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E, CLS82E).
Faster market entry, higher yields, and improved
quality - Real-time, inline bioprocess monitoring and
control from lab to GMP with Raman Rxn systems &
Memosens digital sensors
Kompetenční brožura (CP)
Anglická verze - 06/2024
New version available in English
This eBook highlights the Endress+Hauser inline analysis portfolio for bioprocessing including Raman spectroscopy systems (Raman Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve, flow cell and flow bench, Raman optic system for single use) and liquid analysis sensor technology (Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E, CLS82E) in the Life Science industry.
Faster market entry, higher yields, and improved
quality - Real-time, inline bioprocess monitoring and
control from lab to GMP with Raman Rxn systems &
Memosens digital sensors
Kompetenční brožura (CP)
Česká verze - 09/2024
New version available in English
This eBook highlights the Endress+Hauser inline analysis portfolio for bioprocessing including Raman spectroscopy systems (Raman Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve, flow cell and flow bench, Raman optic system for single use) and liquid analysis sensor technology (Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E, CLS82E) in the Life Science industry.
Raman downstream process measurement of biosimilars -
Alvotech's monitoring of the protein purification process
during ultrafiltration / diafiltration (UF/DF)
Případová studie (CS)
Anglická verze - 06/2024
New version available in English
This case study examines Alvotech's use of Raman systems (Raman Rxn2 analyzer with Rxn-10 probe and Raman flow assembly) to monitor the downstream protein purification process during UF/DF.
Cell line development meets Raman spectroscopy -
KBI Biopharma’s monitoring of a diverse array of cell
lines and cell concentrations in minimal volume for
automated cell cultivation
Případová studie (CS)
Anglická verze - 12/2024
New version available in English
A case study demonstrating how KBI Biopharma uses Endress+Hauser's Raman spectroscopy system (Raman Rxn2 analyzer, Rxn-10 probe, and the Raman flow assembly's flow bench and flow cell) to screen for cell growth performance during cell line development.
Raman downstream process measurement of biosimilars -
Alvotech's monitoring of the protein purification process
during ultrafiltration / diafiltration (UF/DF)
Případová studie (CS)
Česká verze - 09/2024
New version available in English
This case study examines Alvotech's use of Raman systems (Raman Rxn2 analyzer with Rxn-10 probe and Raman flow assembly) to monitor the downstream protein purification process during UF/DF.
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