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Image of a Raman micro flow cell for downstream bioprocessing

Raman flow cell

Reduce downstream bioprocessing costs and ensure safer patient outcomes

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Specs at a glance

  • Wetted materials

    Body: 316L stainless steel
    Window: Proprietary material, optimized for bioprocesses
    Surface finish: Ra 15 with Electropolish to ASME BPE SF4 finish
    Adhesive: USP Class VI and ISO 10993 compatible

  • Sterilization method

    CIP/SIP

Field of application

The Raman flow cell meets the speed demands of downstream by optimizing Raman collection for low-turbidity, low volume samples. Ideally suited for development-scale flow rates, the Raman flow cell allows real-time monitoring, rapid process optimization, and process control for chromatography and other downstream unit operations.

  • Downstream: aggregation, protein crystallization, formula stability, product CQA, protein concentration, buffer excipients

Benefits

  • The Raman flow bench houses a Raman flow cell and easily connects to an Rxn-10 probe paired with a Raman Rxn embedded analyzer, and ensures transferability when used with the Raman flow assembly calibration and verification kit

  • Provides continuous, real-time measurements with high sensitivity for development-scale flow rates  

  • Achieves lower limits of detection through enhancement of the Raman signal  

  • Brings Raman-based process insights and control to downstream bioprocessing unit operations 

  • Raman spectroscopy - advanced optical analysis technology

    Boost plant safety, ensure product quality, and optimize operations. Raman spectroscopy measures the composition and molecular structure of your samples from lab-to-process in real time.

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Handle your core processes easily

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